Dr. Mikell Paige's Laboratory

Location: Mason's Science and Technology Campus

Dr. Mikell Paige's research is in the field of drug discovery. Current projects include the design and synthesis of drugs for the treatment of cancer, emphysema, or addictions. The tools they use include synthetic organic chemistry, computational modeling of ligand-protein interactions, and protein/enzymatic assays for drug characterization. A list of relevant publications are listed as follows:

Liu Y.; Richardson, J.; Tran, T.; Al-Muhtasib, N.; Xie, T.; Yenugonda, V. M.; Sexton, H. G.; Rezvani, A. H.; Levin, E. D.; Sahibzada, N.; Kellar, K. J.; Brown, M. L.; Xiao, Y.; Paige, M. Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. J. Med. Chem. 2013, 56, 3000-3011. PMID: 23540678

De Oliveira, E. O.; Wang, K.; Kong, H. S.; Kim, S.; Miessau, M.; Snelgrove, R. J.; Shim, Y. M.; Paige, M. Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema. Bioorg. Med. Chem. Lett. 2011, 21, 6746-6750. PMID: 21983441

Paige, M.; Burdick, M. D.; Kim, S.; Xu, J.; Lee, J. K.; Shim, Y. M. Pilot analysis of the plasma metabolite profiles associated with emphysematous Chronic Obstructive Pulmonary Disease phenotype. Biochem. Biophys. Res. Commun. 2011, 413, 588-593. PMID: 21925153